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Two people per episode lose a large amount of weight over a six-month treatment program. It shows each person's journey as they work hard to lose the pounds and learn how to live a healthier lifestyle.

A woman is too heavy to have a baby; a man uses food for comfort.

At 45-years-old and weighing 446 pounds, Ronnie is engaged to be married to the love of his life, Cara.

Debbie is 44-years-old and weighs 401 pounds. She never has had a date, or a full time job, and is s...

A man's weight spiraled out of control when he got married; a woman finds comfort in food.

A man weighs 431 pounds; after 17 years of marriage, a former cheerleader weighs nearly 300 pounds.

An overweight woman has faced tragedies, gaining weight with each one.

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A 5'9'' man weighs 630 lb; an overweight rocker has suffered a stroke in the past.