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Comedy meets drama in this quirky Showtime offering which spotlights the versatility of actress Edie Falco. Set in a New York City hospital, this half-hour single camera comedy is about a strong-willed woman balancing a hectic work life with a complex personal life, all the while fighting the health care system along the way.

Kevin invites Jackie for a midnight rendezvous, where he plans to surprise her with a new diamond ring. She promises to be there. O’Hara asks Jackie to help her admit her mother, who is being flown in from London....

Eddie is replaced by a machine; Zoey administers the wrong dose of a painkiller; parents come forward to claim the baby that Akalitus is caring for.

Jackie has to come up with drastic measures to keep Dr. Cooper from exposing her for falsifying an organ donor's file. Besides, Jackie can't take her wedding ring off when she is about to meet Eddie and seeks Dr. O'Hara'...

Jackie has to deal with the consequences of her drug abuse and Zoey's criticism on Jackie's initial treatment of a patient. Also, Jackie falsifies an organ donor's file.

When Jackie addresses a temp nurse's drug abuse, he calls her an hypocrite. In the meantime, Mrs. Akalitus is still responsible for the foundling infant.

After the ex-husband of his date attacked him with a knife, a man is brought to the ER. Meanwhile, Mrs. Akalitus takes care of a foundling who was left at the nurses' station.

An old friend of Jackie's checks into the hospital with terminal lung cancer; Dr. Cooper's mother has a gall bladder attack and reveals a family secret.

A 10-year-old girl needs Jackie's help to care for her mother who suffers from lupus. Furthermore, Mrs. Akalitus manages to taser herself.

Jackie and Kevin consider enrolling Grace in private school; Dr. O'Hara must endure a boy's emotional thanks; Zoey loses a patient.

In episode 103, an elderly patient checks in who has been treating his heart disease with chicken soup; Jackie discusses her daughter's anxiety with Dr. O'Hara; Eddie learns that he is to be replaced by a pill-dispensing...

Jackie substitutes a narcotic for artificial sweetener, and administrator Mrs. Akalitus mistakenly dumps it in her coffee; ER mayhem causes student nurse Zoey to second-guess her choice of career; and an unruly patient s...

Veteran ER nurse Jackie Peyton bends the rules so something positive can be made of a senseless death of a patient, while hiding her own pain killer addiction which she receives from hospital pharmacist Eddie, who just h...