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This is a medical drama about an acclaimed transplant hospital and the team, which hold life and death in their hands everyday. The team is comprised of Dr. Andy Yablonski, the lead surgeon; Dr. Miranda Foster, a woman trying to live up to her father's reputation; Dr. David Lee, a resident more interested in his private affairs; Ryan Abbott, the new transplant coordinator struggling to balance the aspects of his job; Pam Acosta, the surgical nurse and Dr. Sophia Jordan, the head of surgery who needs to keep everyone in line. Every case is viewed from the perspective of the team, the recipient and the donor.
This show is set in Pittsburgh at Three Rivers Medical Center, William H Foster Transplant Wing.

Andy puts Kuol at the top of the donor list for a new heart; cops threaten to seize the money that was raised for Kuol's surgery.

Andy becomes upset when an arrogant heart surgeon, who is also his rival, returns to the hospital

A female firefighter must decide if she should donate part of her lung to her captain, who mistreats her. Meanwhile, Andy's uncle shows up with a stab wound and asks Andy not to report the incident because he fears it wi...

Andy cares for a man in need of a kidney transplant and searches for a suitable donor, and he suspects a recent heart-transplant patient is rejecting his new heart.

Andy cares for a man in need of a kidney transplant and searches for a suitable donor, and he suspects a recent heart-transplant patient is rejecting his new heart

A wealthy man attempts to buy his dying wife a new liver when she is denied a legal transplant. Andy gets a blast from the past when an old shows up at the hospital.

Andy and Sophia treat a car crash victim named Victor dying from ALS who asks to be to taken off of life support so his organs can be used to save others. Meanwhile, David tends to a foster parent with pulmonary hyperte...

Lisa becomes very attached to an 8-year-old boy who she witnesses being crushed by a ride at a fair. Meanwhile, Andy and David try to get a VAD (ventricular assist device) for one of their patients.

In order to save his life, Andy tries a risky new procedure on his wife's partner who suffers from an aortic aneurysm.

Following a bus crash, the parents of a football player must make a heartbreaking decision whether to donate his organs. Meanwhile, Andy and Ryan rush to find a procurement team to give a boy a heart transplant he desper...

In order to save his life, Andy tries a risky new procedure on his wife's partner who suffers from an aortic aneurysm.

Andy and his co-workers are trying to save an 18-year-old college student who suddenly passes out in front of her school.

Andy tells a young pregnant woman who has had a heart attack that only a transplant can save her and the fetus; unexpected complications with the donor's family jeopardize the procedure.